High cortisol levels may indicate chronic stress, Cushing’s syndrome, or adrenal gland tumors, leading to symptoms such as weight gain, high blood pressure, and high blood sugar. Low cortisol levels may suggest Addison’s disease, adrenal insufficiency, or pituitary gland issues, which can cause symptoms like fatigue, weight loss, low blood pressure, and muscle weakness. It’s essential to work with a healthcare provider to interpret test results accurately and determine the appropriate course of action.